Pathogenesis of GERD, treatment and preventive measures

Gastro-oesophageal reflux disease (GERD)is a very frequent pathological condition, especially among the adult population. In this case, it is very significant that about 10% of all patients who undergone a probing study for the esophagus, stomach and duodenum, have GERD with erosive esophagitis.

Pathogenetic justification of disease occurrence

The real factor of this disease isan aggressive environment of gastric juice, while predisposes to its casting into the cavity of the esophagus a relaxed cardiac sphincter. In relation to the latter, it must be said that this condition is due to a hernia of the esophageal aperture of the diaphragm, or because of an unhealthy diet regimen, suggesting a rare abundant diet with rapid incomplete chewing on food, especially at bedtime.

GERD: treatment with pharmacological drugs

As for most diseasesdigestive tract, for GERD treatment is complex, implying the use of several classes of drugs. Among them, antacids and histamine blockers. The first drug group includes the most effective drugs that reduce the concentration of protons in the gastric juice, thereby reducing its acidity, and consequently aggressiveness. These drugs are omeprazole, pantoprozole, lansoprazole, esomeprazole. In fact, they do not fundamentally differ, but it is believed that if a person is concerned about the phenomena of esophagitis and ulceration of the esophagus, the most optimal use of the last two drugs. In this esomeprazole is a "gold standard" among antacids belonging to the class of proton pump blockers. Noteworthy is the fact that even the most senior representative of the class - omeprazole - when taken in a dose of 40 mg is able to completely "disconnect" the secretory tubules for about 4 days in the extra cells of the stomach.

The second group is H2 histamine blockersreceptors. Suppression of their activity does not allow histamine to contact him, and hence activate the release of enzymes and acid by the glands of the walls of the stomach. At the same time, from a very wide variety of drugs the physician chooses the most optimal combination with fewer side effects for a particular patient.

GERD: treatment associated with the regimen

For the pathology of GERD, treatment includes not onlythe above pharmacological agents, but also changes in lifestyle. Among them, such preventive measures as a rational diet, the essence of which is the frequent fractional intake of small portions of food with a thorough chewing. It is unacceptable that the food or food used is injured or adversely affected by the esophagus, therefore hot food should be excluded for the duration of treatment (maximum 2 months). In this case, you can eat warm food, not salted and spicy. It is also worthwhile to refrain from fruits and juices, since they have a direct traumatic effect due to organic acids.

Very important for diet is adequaterest after eating. Many people whose GERD disease is just starting to develop, quickly respond to the so-called specific dynamic effect of food, which increases the body temperature by 1 degree, there is drowsiness. As a result, patients simply go to bed. However, a person after eating should be about 1,5-2 hours in an upright or sitting position, that is, in a posture, when the distended walls of the stomach are not allowed to happen to throw the contents into the esophagus.