Medication "Lasix": indications for use, contraindications and reviews

What is the drug "Lasix" for? Indications for the use of this medication will be listed below. In addition, we will tell you about what contraindications are available for the medication in question, in what form it is released, what is included in its composition, whether it has side effects and analogues.

Composition and forms

Currently, you can buy the drug in the following forms:

• Tablets "Lasix". Reviews say that they are white, roundform and risk in the middle. The active substance of this drug is furosemide. It also includes auxiliary components in the form of lactose, starch, pregelatinized starch, talc, colloidal dioxide and magnesium stearate. The medicine is produced in strips of aluminum foil, which are placed in cardboard packages.
• Solution for intramuscular or intravenous administration of "Lasix" (ampoules). The instruction says that the active element of this form is also furosemide.

Features of the medicinal product

What is the drug "Lasix"? Indications for use of this medication are described in the attached instructions. It also indicates the mechanism of action of the drug.

"Lasix" - high-speed and quite strongdiuretic, which is a sulfonamide derivative. It blocks the transport system of sodium and chlorine ions in the thick section of the ascending knee of the Henle loop. Thus, the diuretic effect of this drug depends on its entry into the lumen of the renal tubules.

The secondary effects of this medication are an increase in potassium secretion in the distal segments of the renal tubule and the amount of urine released.

At course treatment diuretic activitythe medicine does not decrease. With heart failure, the drug "Lasix" quickly reduces preload, as well as pressure in the pulmonary artery and the left ventricle.

This drug has an antihypertensive effect, which is caused by an increase in sodium excretion, a decrease in the volume of circulating blood, and a decrease in the reaction of smooth muscles.

Pharmacokinetics of the drug

"Lasix" is a diuretic that quicklyabsorbed from the digestive tract. Its bioavailability in different people can be reduced to 30%. This is due to the fact that it can be influenced by absolutely any factors, including the underlying disease.

The drug binds well to plasma proteins (about 98%). It is excreted unchanged through the kidneys and through the intestines.

It should also be noted that "Furosemide" penetrates quite well through the placental barrier and is excreted together with the mother's milk.

The drug "Lasix" (injections): indications for use

In what diseases can a medication be administered in the form of a solution? According to the instructions, the drug "Lasix" (analogues will be presented below) is used for:

• edematous syndrome with heart failure (chronic);
• edema of the brain;
• edematous syndrome with renal failure (chronic);
• hypertensive crisis;
• acute renal failure, including those observed with burns and pregnancy (to support fluid excretion);
• edematous syndrome with nephrotic syndrome;
• arterial hypertension;
• edematous syndrome with liver diseases;
• as a support for forced diuresis for poisoning with chemicals that are excreted by the kidneys unchanged.

Tablets "Lasix": indications for use

Take the drug in the form of tablets should bethe same indications as described above. However, experts argue that the solution for intramuscular or intravenous administration is much more effective.

Contraindications for use

What states of the patient prohibit taking Lasik? Contraindications to the use of this drug are listed in the attached instructions. Let's consider them right now:

• severe hyponatremia;
• renal failure with anuria;
• digitalis intoxication;
• hepatic precoma and coma;
• acute glomerulonephritis;
• pronounced hypokalemia;
• period of pregnancy;
• hypovolaemia or dehydration;
• breast-feeding;
• marked disturbances of urinary outflow;
• hyperuricemia;
• decompensated mitral and aortic stenosis, as well as hypertrophic obstructive cardiomyopathy;
• children's age to three years (tablets form);
• increased central venous pressure;
• hypersensitivity to the components of the drug;
• an allergy to furosemide.

General dosage of the preparation and its methods of use

How to take Lasik? The dosage of this drug depends on the type of disease.

Tablets must be taken whole, on an empty stomach. When prescribing a medication, it should be used in minimal dosages that are sufficient to achieve a therapeutic effect.

The recommended maximum daily dose forof adults is 1500 mg. As for children, it depends on the weight of the patient (2 mg / kg, but not more than 40 mg per day). The duration of therapy is determined by a specialist individually and depends on the indications.

Side effects

Now you know how to take Lasik. Use this medication only as directed by your doctor. This is due to the fact that it has a fairly large number of adverse reactions. Let's consider their list right now.

• headaches, muscle weakness, confusion, heart rhythm disturbances, convulsions;
• drowsiness, dyspeptic disorders, weakness, collapse, dry mouth;
• hypomagnesemia, hypochloraemia, hyponatremia, hypocalcemia, hypokalemia, metabolic alkalosis;
• dizziness, decreased glucose tolerance, increased serum triglyceride and cholesterol levels;
• nausea, hematuria, vomiting, excessive decrease in blood pressure, decreased potency;
• diarrhea, hearing impairment, constipation, tinnitus, nephrotic syndrome;
• allergic reactions: interstitial nephritis, skin itching, leukopenia, urticaria, exfoliative dermatitis, bullous skin lesions, fever, erythema polymorphic, eosinophilia, purpura, vasculitis, photosensitivity;
• agranulocytosis, thrombocytopenia, hemolytic or aplastic anemia.

Drug Interactions

According to the instructions, the drug "Lasix", which will be reviewed further, has the following drug interactions:

• "Karbenoksolon", glucocorticosteroids and licorice in large doses, as well as prolonged use of laxatives combined with furosemide increase the risk of hypokalemia.
• Drugs with nephrotoxic effect increase the risk of nephrotoxic effect.
• Aminoglycosides with simultaneous application with furosemide increase the risk of nephrotoxic and ototoxic action of the first.
• High dosages of cephalosporins increase the risk of nephrotoxic action.
• NSAIDs, as well as acetylsalicylic acid, reduce the diuretic effect of furosemide.
• "Phenytoin" reduces the diuretic effect of furosemide.
• "Methotrexate" and "Probenicid" reduce the effects of furosemide.
• With the combination of "Cyclosporine A" and furosemide, the risk of arthritic arthritis increases.

Special recommendations for the use of the drug

Before applying the drug "Lasix", the indications of which were presented above, it is necessary to exclude the presence of severe violations of the outflow of urine.

During therapy, regular serum concentrations of potassium, sodium and creatinine should be monitored.

When treating "Lasik" it is advisable to consume potassium-rich foods. In some cases, potassium-sparing drugs may be recommended.

Analogues of the medicinal product

Structural analogues of the drug in question(according to the active ingredient) are such drugs as "Furosemide", "Furon" and "Fursemide". Also, the medication "Lasik" can be replaced with "Acrypamid", "Brinaldix", "Veroshpironom", "Hypothiazidom", "Diuverom", "Indapom", "Klopamidom", "Lorvas", "Mannitol", "Spironolom", "Uraktonom" and other medicines.

Patients' feedback about the drug

Now you know the purpose for whichmedicament "Lasix". Indications for use of this medication have been described above. What do patients say about it? Virtually all people taking this medication note its high effectiveness. However, very many patients complain of the occurrence of a large number of adverse reactions (headaches, nausea, etc.). However, experts argue that when taking minimal doses, these phenomena occur extremely rarely.