Effective spasmolytic agent "Papaverine hydrochloride"

The drug "Papaverine hydrochloride" refers toMyotropic agents with a strong antispasmodic effect. For many decades it has been used to reduce the tone and relaxation of the vessels and smooth muscles of almost all internal organs. It has a pronounced hypotensive effect. This drug expands the arteries, contributes to an increase in the amount of blood flow, in particular, cerebral. This drug in elevated doses dramatically reduces the excitability of the musculature of the heart, and also contributes to the slowing of intracardiac conductivity. Its effect on the central nervous system is slightly pronounced, although at elevated dosages it has some sedative effect.

They release the drug "Papaverine hydrochloride" in such dosage forms:

- tablets for adults at 0,04 g (10 pcs.);

- Children's tablets for 0,01 g (10 pcs.);

- 2% solution for injections (10 ampoules each);

- Suppositories rectal by 20 mg (10 pieces each).

Indications for use are such states,as spasms of smooth muscles of the peritoneal organs with cholecystitis, renal colic; spastic colitis; endarteritis; bronchospasm; pilorospazme; spasms of vessels located in the brain. In the treatment of angina papaverina hydrochloride is used for complex therapy with other drugs.

Contraindications to the use of this drug are:

hypersensitivity, dysfunction of the liver, glaucoma, children's age (up to 0.5 years). In the elderly, you can not take this drug, because there is a risk of hyperthermia.

Means of "Papaverine hydrochloride": instructions for use

The drug is taken 3-4 p. per day. The dosage for a single tablet intake varies depending on the age of the patient. Adults appoint a single dose of tablets of 40-60 mg. Children 0.5-2 grams - 5 mg, 3-4 grams - 5-10 mg, 5-6 liters. -10 mg, 7-9 liters. - 10-15 mg, 10-14 liters. - 15-20mg.

The solution for injection is administered intramuscularly orsubcutaneously. Injections make 2-4 p. per day for 1-2ml. Intravenously, the drug is administered very slowly by 20 mg, previously adding 10-20 ml of sodium chloride (0.9% solution) to it. This procedure is best performed under the supervision of the attending physician. For patients at the age of a single initial dose should not be more than 10 mg. Often, this drug is administered parenterally in combination with various spasmolytic and analgesic drugs, such as the drug Promedol.

Candles with papaverine inject rectally, 2-3 r. per day for 20-40 mg.

The drug "Papaverine hydrochloride" can causesuch side effects as drowsiness, allergic reactions, ventricular extrasystole, increased liver transaminase activity, lowering of blood pressure, constipation, eosinophilia.

When an overdose of the drug, symptoms such as general weakness, diplopia, increased drowsiness are noted.

With the use of this drugspecial instructions should be followed, which recommend careful use of the drug to weakened and elderly patients; people with craniocerebral injuries, hypothyroidism, adrenal, kidney and liver disorders; with tachycardia; shock states.

The drug "Papaverine hydrochloride" during pregnancy and during feeding is better not to use, because its effectiveness and safety in such periods is not established.

During therapy, alcohol is prohibited. Smoking during treatment significantly reduces the effectiveness of the drug. With the simultaneous receipt of funds "Papaverine" and "Dopegitom" significantly reduced the effect of the first.

Papaverine hydrochloride is included in several combined antispasmodic agents in combination with other medicinal substances:

- the drug "Lupaverine" - with phenobarbital;

- preparation "Pafillin" - with platifillin hydrotate;

- preparation "Kellatrin" - with kellin and atropine sulfate;

- "Kelliverin" preparation - with kellin;

- drug "Nicoverin" - with nicotinic acid.

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