"Moxonidine": instructions for use, reviews
What is Moxonidine? Instructions on the use of this tool, reviews about it, contraindications and analogues will be described in detail in this article. In addition, we will tell you about what is intended by the means we are considering, whether it has side effects and in what form it is produced.
Form and composition of the medicament
In what form can you take medicine"Moxonidine?" This drug is sold only in the form of tablets. Their active element is a substance such as moxonidine. As for the additional components, they include microcrystalline cellulose, castor oil, aerosil A-380, hydroxypropyl cellulose, magnesium stearate and tween-80.
Tablets are sold in a cardboard bundle. In one package there may be 98, 60, 56, 42, 40, 30, 28, 20, 14 and 10 tablets.
Pharmacological properties of the drug
Why do I need a Moxonidine medication? The instruction for use states that this drug is an antihypertensive drug. Its mechanism of action lies in the fact that the active substance of the agent affects the central links of the regulation of blood pressure. In other words, moxonidine is an imidazoline receptor agonist (to a greater extent).
The drug inhibits vasomotor activitycenter, reducing the descending sympathetic effects on the cardiovascular system. At the same time, the pressure (both diastolic and systolic) decreases gradually.
The drug we are considering is different fromother hypotensive sympatholytic agents in that it has only a small kinship with alpha-2-adrenergic receptors. This explains the low probability of dry mouth and sedative effect.
One can not help saying that moxonidine is able to increase the index of insulin sensitivity (by about 21 percent) in obese people.
Pharmacokinetics of the drug
Where is Moxonidine absorbed? Instructions for use says that after taking the medication instantly and almost completely absorbed in the upper parts of the digestive tract.
Bioavailability (absolute) of this agentis 88 percent. The maximum concentration is achieved in sixty-five minutes. At the same time, eating does not have any effect on the pharmacokinetics of the active element.
The connection with blood proteins is about 7.3%. The main metabolite of moxonidine is moxonidine dehydrogenated, as well as derivatives of guanidine.
The half-life of moxonidine and its metabolites is 150 and 300 minutes, respectively.
After oral administration for twenty-four hours, the drug is excreted by the kidneys in a volume of 90%. Also, the active substance exits through the intestine.
Indications for the use of a medical device
In what cases is a "Moxonidine" medication prescribed? The use of this drug is shown only with such pathology as arterial hypertension.
Contraindications to the use of a medical device
In what cases do doctors not prescribe theirpatients with the drug "Moxonidine"? Instruction for the use of this drug contains a not very long list of contraindications. Consider it right now.
So, contraindications to the use of the drug "Moxonidine" are the following factors:
- expressed AV blockade of 2 and 3 degrees, SSSU;
- pronounced bradycardia (less than 50 beats per minute);
- adolescence and children's age (up to 18 years);
- chronic and acute heart failure;
- period of feeding the baby;
- Hypersensitivity to the active element.
Medication "Moxonidine": instructions for use
Patients' comments about this medication will be presented at the very end of the article. Now I want to tell you about how to properly use the drug we are considering.
The drug "Moxonidine" is taken only by mouth. Dosage at the beginning of drug therapy should be 200 μg once a day. At a time you can take 400 mcg.
Individual adjustment of the dailyvolume of the drug, depending on the tolerability of drug therapy. According to the instructions, the maximum dosage of the drug per day is 600 μg (divided into two doses).
For patients with renal insufficiency (severeand medium degree), and also to people who are on hemodialysis, the drug is prescribed in the amount of 200 μg once a day. If necessary (with good tolerability), then the indicated dosage can be increased to the maximum (that is, up to 400 μg).
Side effects after taking medication
Are side effects caused by Moxonidine? The patient's comments about him say that sometimes a medicine really becomes a cause of deterioration of well-being.
- Nervous system (central): headaches, fainting, dizziness and drowsiness.
- Digestive tract: vomiting, dry mouth, diarrhea, dyspepsia and nausea.
- System cardiovascular: aetiology, pronounced lowering of arterial pressure, orthostatic hypotension.
- Skin and subcutaneous tissue: angioedema, itching and skin rash.
- Mental disorders: nervousness and insomnia.
- Labyrinth disorders of the hearing: ringing in the ears (it happens very rarely).
- Musculoskeletal system: back pain, neck pain.
- Common side effects: peripheral edema and asthenia.
As you can see, Moxonidine tablets can cause deterioration of the patient's condition. If the side effects are clearly pronounced, then the medication should be stopped.
Interaction of the drug with other drugs
To drugs "Moxonidine", "Moxonidine Sandoz"and other analogues of the medication have helped the patient, and not caused him more harm, they should be taken only as directed by the doctor. Because the simultaneous use of this drug with other drugs can cause unwanted reactions. Which ones, we will consider right now.
A single use of the drug "Moxonidine" with similar antihypertensive drugs can lead to an additive effect.
Antidepressants (tricyclic) reduce the effectiveness of antihypertensive drugs of central action. In this regard, they are not recommended to be used in conjunction with a substance such as moxonidine.
The drug under consideration can easily enhance the action of tranquilizers, tricyclic antidepressants, as well as ethanol, hypnotics and sedatives.
The active substance of the drug moderately improves the weakened cognitive functions of people who simultaneously receive lorazepam.
With the simultaneous administration of "Moxonidine" and "Benzodiazepine" preparations, the sedative effect of the derivatives of the latter may be enhanced.
Specialists say that moxonidine is excreted by tubular secretion. In this regard, it should not be used together with drugs that are also secreted through tubular secretion.
The period of gestation and breastfeeding (pregnancy and lactation)
Is it possible to take in the period of gestationmedicine "Moxonidine-LF"? The drug's instruction contains information that strictly controlled and adequate studies on the safety of the drug in question have not been carried out during pregnancy. That is why it is not recommended to apply this category of patients.
It is impossible not to say that the drug"Moxonidine" should not be used during breastfeeding. This is due to the fact that it is excreted together with the mother's milk. If the drug was still prescribed during lactation, then breastfeeding should be stopped.
In the course of research (experimental) in animals, it was found that this medication acts embryotoxically.
Special instructions on the use of medicament
According to the attached instructions, during theuse of the drug "Moxonidine" should be very careful. This is especially true for a particular category of patients. Which one, we'll tell right now.
Particular caution in the use of medicinalof the drug "Moxonidine" should be observed patients with AV-blockade of the 1st degree. This is due to the fact that these people have a high risk of developing a bradycardia.
Also, the medication should be taken underthe doctor's control in severe coronary artery disease, kidney failure and unstable angina. This fact is due to the fact that the experience of using the drug with such deviations is insufficient.
If it is necessary to cancel the simultaneous use of "Moxonidine" and beta-blockers, the last remedy is first canceled, and in a few days - the second.
To date, there is no information that,that the discontinuation of the drug "Moxonidine" leads to an increase in blood pressure. However, despite this, experts still recommend gradually canceling the medication. Dosage should be reduced for two weeks.
Does the drug affect the ability to drive cars?
During the period of drug drug treatment"Moxonidine" people should be especially careful when engaging in hazardous activities, as well as while driving motor vehicles. This is due to the fact that taking a medication can disrupt concentration and psychomotor reactions.
Analogues and cost of a medicinal product
You can buy the drug "Moxonidine" in a pharmacywithout a doctor's prescription. The cost of this medication is relatively low. For the package, which contains 14 tablets, you will have to pay approximately 115-135 Russian rubles.
If the drug we are consideringyou did not fit or you just could not find it in the pharmacy, then after consulting a specialist, the latter is obliged to recommend you some kind of analogue of the drug. Among these medicines I would like to highlight the following: "Physiotenses", "Moxonidine-C3", "Moxarel", "Moxonidine Canon", "Moxonitex", "Moxogamma", "Tenzotran" and so on.
Take these funds should be strictly according to the appointment of a specialist. Also, before using the medication, it is necessary to read the attached instructions.
Medication "Moxonidine": reviews of doctors and patients
According to experts, this drugis very effective in hypertension. The same opinion is shared by patients. However, some of them complain that after taking the pills after a while they have such side effects as headaches, dry mouth, nervousness and nausea. In this case, doctors recommend to cancel the drug and replace it with an analogue, which will be safer for health.
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